Formulation of Microsphere with Antihelmintic Drug

ISBN-13: 9783848401321 / Angielski / Miękka / 2012 / 104 str.

Chirag A Patel;Viren Patel;Girish N Patel

Opis

The present research works carried out with the aim to prepare suspension dosage form using these microparticles for oral use. Solid Dosage forms are difficult for Pediatric, Geriatric patient & Dysphasic patients so for that patients the suspension dosage form more favorable than other solid dosage form. Albendazole drug has poor oral bioavailability (>5%) & a delayed release microspheric suspension of this drug would improve patient compliance & ease of swallowing. Microencapsulate facilitate the targeting of drug & mask the metallic taste of drug. The % yield was higher in the solvent evaporation method, in the spray drying the % yield was less that was drawback of the spray drying method. The % entrapment efficiency was good in the both method. Spray drying method is more reproducible than the solvent evaporation method. The stability study results show similar values as at the initial time. So, the formulation was stable and had no significant change in drug release profile & drug content on storage for a long time. So the suspension can effectively used for pediatric and geriatric patients. In vivo study will use for confirmatory study.

O autorze

Mr.Chirag A.PatelM.Pharm,Assistant Professor,Kalol Institute Of Pharmacy,Kalol,Gujarat,India