Neurotrophic Factors and Their Receptors : The structural and functional studies of GDNF and MANF/CDNF family of neurotrophic factors

ISBN-13: 9783838322469 / Angielski / Miękka / 2009 / 92 str.

Vimal Parkash

Opis

Four GDNF ligands (GDNF, neurturin, artemin and persephin), and mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF) protect midbrain dopaminergic neurons that degenerate in Parkinson's disease. Each GDNF ligand binds a specific coreceptor GDNF family receptor (GFR ), leading to the formation of a heterotetramer complex, which then interacts with receptor tyrosine kinase RET, the signalling receptor. The present work describes the structural and biochemical characterization of the GDNF-GFR 1 complex and the MANF and CDNF proteins.

O autorze

Vimal Parkash, Ph.D. in Biochemistry from University of Helsinki, Finland, Postdoctoral researcher at the university of Helsinki in Adrian Goldman's laboratory.