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The treatment of root fracture may be a painstaking job for both dentists and patients. Therefore, an evidence-based clinical approach should be followed for the successful treatment of root fractures. The clinician should have a thorough knowledge of aetiological cause of fracture, classic signs and symptoms of fracture, availability and applicability of diagnostic methods, differential diagnosis, and factors determining the prognosis, so as to arrive at an appropriate diagnosis and design a suitable treatment protocol. This helps in distinguishing between restorable and non-restorable...

Biopharmaceutical innovation has had a profound health and economic impact globally. Developed countries have traditionally been the source of most innovations as well as the destination for the resulting economic and health benefits. The rapid pace of discovery in the biotechnological sciences has created substantial difficulties for the Federal food and Drug Administration (FDA), European Union and all major regulators, which ensures the safety and efficacy of biopharmaceutical products. The speed of biotechnological discovery necessarily requires rapid product approval by regulators, as...