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This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead...

The seering cultural history of the last half-century, The Age of American Unreason In A Culture of Lies focuses on the convergence of social forces--usually treated as separate entities--that has created a perfect storm of anti-rationalism. These include the upsurge of religious fundamentalism, with more political power today than ever before; the failure of...

Shame is one of our most central feelings and a universal human characteristic. Why do we experience it? For what purpose? How can we cope with excessive feelings of shame?

In this elegant exposition informed by many years of helping people to understand feelings of shame, leading Jungian analyst Mario Jacoby provided a comprehensive exploration of the many aspects of shame and showed how it occupies a central place in our emotional experience. Jacoby demonstrated that a lack of self-esteem is often at the root of excessive shame, and as well as providing practical examples of how...

• Umfassende Kommentierung der 631-651 BGB
• Erlauterung der Gewahrleistung nach der VOB/B
• Informationen zu BauFordSiG, insolvenzrechtliche Bezugen und zum Bautragervertrag
• Ausfuhrung zu Gewahrleistung/Haftung des Architekten und anderer Sonderfachleute
• Erorterung praxisrelevanter Fragen zur Abtretung von Gewahrleistungsanspruchen
• Ausfuhrungen zur Haftung der Parteien untereinander/Ausgleich bei gemeinschaftlicher Haftung gegenuber Dritten
  

In Never Say Die, Susan Jacoby delivers a brave, impassioned, and exceptionally important wake-up call to Americans who have long been deluded by the dangerous myth that a radically new old age awaits the huge baby boom generation.
Combining historical, social, and economic analysis with personal experiences of love and loss, Jacoby unmasks the fallacies promoted by twenty-first-century hucksters of longevity, and reveals the hazards of the magical thinking that prevents us from facing the genuine battles of growing old. Never Say Die speaks to Americans, whatever their...

"In der Philosophie der Gegenwart fehlt es an einem systematischen Lehrbuche uber die verwickelten Strukturverhaltnisse, die unseren alltaglichen und wissenschaftlichen Wirklichkeitsbegriffen zu Grunde liegen. Das vorliegende Buch versucht, diese Lucke auszufullen. Dem umfassenden Feld seiner Aufgabe entsprechend wendet es sich nicht nur an den engeren Kreis der Fachphilosophen, sondern zugleich an den weiteren Kreis aller derjenigen, denen der Wirklichkeitsbegriff ihres Arbeitsgebietes ein Problem ist." "(Aus dem Vorwort zu Band I)"

Der Greifswalder Philosophieprofessor Gunther Jacoby...