Medical Implications of Biofilms

ISBN-13: 9780521812405 / Angielski / Twarda / 2003 / 338 str.

Michael Wilson (University College London); University of Leeds) Deirdre Devine (Leeds Dental Institute

Opis

Interest in biofilms has increased dramatically in recent years. New microscopic and molecular techniques have revolutionized our understanding of biofilm structure, composition, organization, and activities. This book brings advances in the prevention and treatment of biofilm-related diseases to the attention of clinicians and medical researchers. Human tissues often support complex microbial communities growing as biofilms that can cause infections. As microbes in biofilms exhibit increased tolerance toward anti-microbial agents and decreased susceptibility to host defense systems, biofilm-associated diseases have become increasingly difficult to treat.

Recenzje

Review of the hardback: '… a valuable reference both for biofilm aficionados and anyone, including final-year undergraduates, with an interest in infectious diseases.' Microbiology Today

Spis treści

Part I. Introductory Chapters: 1. Biofilm-dependent regulation of gene expression P. LeJeune; 2. Quorum sensing and microbial biofilms T. R. de Kievit; 3. Antimicrobial agents and biofilms M. R. Brown; Part II. Biofilms on Prosthetic Devices: 4. Animal models of orthopaedic implant infection Y. H. An; 5. Intravascular-catheter-related infections H. A. Hanna; 6. Molecular basis of biofilm formation by staphylococcus epidermidis C. Heilmann; 7. Biofilm complications of urinary tract devices S. P. Gorman; Part III. Oral Biofilms: 8. Novel microscopic methods to study the structure and metabolism of oral biofilms D. Bradshaw; 9. Oral streptococcal genes that encode biofilm formation C. Y. Loo; 10. Gene expression in oral biofilms R. A. Burne; Part IV. Biofilms on Shedding Surfaces: 11. Dissection of the genetic pathway leading to multicellular behaviour in salmonella enterica serotype typhimurium and other enterobacteriaceae U. Romling; 12. Bacterial growth on mucosal surfaces and biofilms in the large bowel G. T. Macfarlane; 13. Pseudomonas aeruginosa biofilms in lung infections K. K. Jefferson.