Neurotransmission in the Hippocampus

ISBN-13: 9783540188001 / Angielski / Miękka / 1988 / 105 str.

Michael Frotscher; Peter Kugler; Ulrich Misgeld

Opis

This volume provides an interdisciplinary approach to this central research topic. Firstly, the hippocampus is presented generally as a model for experiments on neurotransmission in the central nervous system; secondly, special features of synaptic organisation and synaptic transmission in this area of the brain are introduced. Of particular note is the wide-ranging methodological approach which includes light and electron microscopy, immunocytochemistry, Golgi/EM techniques, intracellular differentiation and intracellular colorings, histochemistry of transmitter enzymes and receptoraudiography. The reader thereby gains insight into the broad scope of methodological possibilities for the examination of such a complex problem as neurotransmission in the hippocampus.

Spis treści

1 Introduction.- 2 Neuronal Elements in the Hippocampus and Their Synaptic Connections.- 2.1 Hippocampal Neurons.- 2.1.1 Pyramidal Cells in CA1.- 2.1.2 Pyramidal Cells in CA3.- 2.1.3 Dentate Granule Cells.- 2.1.4 Nonpyramidal Neurons.- 2.2 Synaptic Connections of Identified Neurons in the Hippocampus.- 2.2.1 Principles of Hippocampal Innervation.- 2.2.2 Extrinsic Afferents to the Hippocampus and Fascia Dentata.- 2.2.2.1 Entorhinal Afferents.- 2.2.2.2 Cholinergic Fibers.- 2.2.2.3 Commissural Afferents.- 2.2.3 Intrinsic Connections.- 2.2.3.1 Mossy Fibers.- 2.2.3.2 GABAergic Terminals.- 2.3 Functional Implications.- 3 Membrane Properties and Postsynaptic Responses of Hippocampal Neurons.- 3.1 Various Cell Types in the Slice Preparation.- 3.2 Short-Distance Excitatory Connections.- 3.3 GABAergic Inhibition.- 3.4 Cholinergic Excitation.- 3.5 Conclusions.- 4 The Enzyme Histochemistry of Neurotransmitter Metabolism.- 4.1 Enzymes Related to the Cholinergic Transmitter System.- 4.1.1 Acetylcholinesterase.- 4.2 Enzymes Related to the Amino Acid Transmitter System.- 4.2.1 Enzymes in Glutamate Metabolism.- 4.2.1.1 Aspartate Aminotransferase.- 4.2.1.2 Glutamate Dehydrogenase.- 4.2.1.3 Glutaminases.- 4.2.2 Enzymes in GABA Metabolism.- 4.2.2.1 GABA Transaminase.- 4.3 Conclusions.- 5 Receptor Autoradiography in the Hippocampus of Man and Rat.- 5.1 Quantitative Receptor Autoradiography as a Functional Approach.- 5.2 Distribution of Receptors in the Hippocampus of the Rat.- 5.2.1 5-HT System.- 5.2.2 Cholinergic System.- 5.2.3 Glutamate System.- 5.2.4 Colocalization of Different Receptors on the Level of Hippocampal Layers.- 5.3 Distribution of Binding Sites in the Human Hippocampus.- 5.3.1 5-HT1 System.- 5.3.2 Glutamate System.- 5.4 Comparison of Receptor Distribution in the Hippocampus of Rat and Man.- 5.4.1 5-HT System.- 5.4.2 Glutamate System.- Concluding Remarks.- Summary.- References.

O autorze

Prof. Dr. Peter Kugler, ist Professor der Neuroanatomie an der Universität Würzburg und Mitautor von anatomischen Lehrbüchern. Prof. Dr. med. K. Zilles, Direktor des Instituts für Hirnforschung und des Instituts für Neuroanatomie der Universität Düsseldorf; Leiter des Instituts für Medizin im Forschungszentrum Jülich.