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Current trends in morbidity suggest that by the beginning of the twen ty-first century, psychiatric illness may become the most pressing problem in public health in many of the advanced countries. As ably demonstrated by Vandenberg, Singer, and Pauls, the principal identifia ble etiology of the major psychiatric disorders is heredity; if progress is to be made in prevention and treatment of these disorders, it may have to come from improved understanding of their inheritance. A relentless increase has been observed in the frequency of mood disorders, primarily major depression but also...