Saraca indica against Cyclophosphamide induced cardiotoxicity

ISBN-13: 9783848480913 / Angielski / Miękka / 144 str.

Uchit Patel; Sudhir Sojitra; Nikunj Patel

Opis

The study was designed to evaluate the cardioprotective potential of Saraca indica (SI) herb extract on the basis of biochemical, electrocardiographic and histopathological parameters in cyclophosphamide (CP) induced myocardial toxicity. Cardiotoxicity was induced in rats by administering cyclophosphamide (200 mg/kg, i.p.) single injection. SI (200 and 400 mg/kg, p.o.) were administered immediately after administration of cyclophosphamide on first day and daily for 10 days. The general observations, ECG, Level of biomarkers, serum enzymes, Lipid profiles, antioxidant enzymes, level of myocardial infarction & Histopathological changes were estimated. The Reports indicates that Saraca indica treatment produced dose dependent protective effect in ameliorating the biochemical, histopathological and electrographic abnormities caused by CP administration.

O autorze

Uchit M. Patel has completed his B.Pharm from Vidyabharti Trust college of Pharmacy, Bardoli in year 2009 and recently completed his M.Pharm from KLE University's College of Pharmacy,Hubli. Now a days he is working with a Reputed Pharmaceutical Company in a Regulatory Affairs Department.