Anoikis: How the Extracellular Matrix Regulates Life-Or-Death Decisions

ISBN-13: 9783030738549 / Angielski / Twarda / 2021 / 202 str.

Steven Frisch

Spis treści

Preface

Introduction

Chapter 1 The intersection of anoikis resistance and fatty acid metabolism in cancer

Chapter 2 Anoikis resistance in melanoma

Chapter 3 Anoikis mediated by stress-activated MAPK signaling pathways

Chapter 4 Metabolic Regulation of Anoikis

Chapter 5 Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells

Chapter 6 Role of the nuclear receptors in anoikis

Chapter 7 The roles of anoikis in cervical cancer

Chapter 8 Shc and the control of small GTPase dynamics in cellular anchorage

Chapter 9 Anoikis and the Human Gut Epithelium in Health and Disease

Chapter 10 Epithelial cell extrusion:  the prelude to anoikis

Chapter 11 Microtubule modifications and mitochondria:  role in anoikis

O autorze

Steven M. Frisch received his Ph.D. in Biochemistry from the University of California, Berkeley (where he worked with Dr. Zena Werb, at U.C.S.F). Following postdoctoral training at the M.I.T. Center for Cancer Research, Dr. Frisch served on the faculties of Washington University, St. Louis and the Sanford-Burnham-Prebys Institute, and is currently a Professor of Biochemistry at West Virginia University. Dr. Frisch has published extensively in the area of cancer cell biology and is internationally recognized for his important contributions to the field.

Blurb

This book provides a useful resource for graduate-level cancer cell biology courses. Since the first report, in 1994, of “anoikis”—the apoptosis that occurs when cells lack appropriate contact with the extracellular matrix—over 2,100 papers have been published on this subject. This book is the first comprehensive, in-depth and up-to-date compendium on anoikis. Chapters are authored by some of the leading researchers in the field.

This book provides both mechanistic and translational information regarding anoikis, in a convenient format.  Mechanistically, the following topics will be addressed in detail:

•  The role of MAP kinase signaling 
• The role of Shc proteins as cellular anchorage sensors 
• The role of cellular metabolism, and fatty acid metabolism in particular,  and how they are affected by oncogenic transformation 
• How epithelial cell extrusion – the prelude to anoikis—is regulated in normal and cancer cells
• The convergence of TGF-b and androgen receptor signaling in the regulation of anoikis 

This book also discusses the specialized functions and dysregulation of anoikis in the following cancer settings: 

• Colon cancer 
• Melanoma 
• Cervical cancer 

The book serves to update i nvestigators actively working on problems in the anoikis field, in either experimental or translational settings. For investigators encountering novel biological phenomena that might relate to anoikis, it serve as an entry point to the literature that does not require an extensive background in cell adhesion signaling or apoptosis mechanisms.