Physiology

ISBN-13: 9781468445763 / Angielski / Miękka / 2013 / 411 str.

Sherwood M. Reichard; James P. Filkins; Sherwood M. Reichard

Opis

This comprehensive treatise on the reticuloendothelial system is a project jointly shared by individual members of the Reticuloendothelial (RE) Society and bio- medical scientists in general who are interested in the intricate system of cells and molecular moieties derived from those cells which constitute the RES. It may now be more fashionable in some quarters to consider these cells as part of what is called the mononuclear phagocytic system or the lymphoreticular system. Nevertheless, because of historical developments and current interest in the subject by investigators from many diverse areas, it seems advantageous to present in one comprehensive treatise current information and knowledge con- cerning basic aspects of the RES, such as morphology, biochemistry, phylogeny and ontogeny, physiology, and pharmacology as weIl as clinical areas including immunopathology, cancer, infectious diseases, allergy, and hypersensitivity. It is anticipated that by presenting information concerning these apparently heterogeneous topics under the unifying umbrella of the RES attention will be focused on the similarities as weIl as interactions among the cell types constitut- ing the RES from the viewpoint of various disciplines. The treatise editors and their editorial board, consisting predominantly of the editors of individual vol- umes, are extremely grateful for the enthusiastic cooperation and enormous task undertaken by members of the biomedical community in general and especially by members of the American as weIl as European and Japanese Reticuloendothe- lial Societies.

Spis treści

I. Fundamental Mechanisms and Regulation of Phagocytosis.- 1. Surface Forces in Phagocytosis.- 2. Regulation of Mononuclear Phagocyte Proliferation.- 3. Quantitation of Macrophage Phagocytosis in Vitro.- 4. Kinetics of Vascular Clearance of Particles by Phagocytes.- 5. Vascular Clearance of Microorganisms.- 6. RES Control of Endotoxemia.- II. Regulatory Interactions with the Blood Elements.- 7. The Reticuloendothelial System and Erythropoiesis.- 8. Erythroclasia and Bilirubin Metabolism.- 9. Hemostasis.- 10. Platelets.- 11. RES-Leukocyte Interactions.- III. Regulatory Interactions with Blood Metabolites and Constituents.- 12. Glucose Regulation and the RES.- 13. Interaction of the Reticuloendothelial System with Blood Lipid and Lipoprotein Metabolism.- 14. Selected Aspects of Protein Metabolism in Relation to Reticuloendothelial System, Lymphocyte, and Fibroblast Function.- 15. Iron Metabolism.- 16. Lead and Cadmium: Effect on Host Defense Mechanisms and Toxic Interactions with Bacterial Endotoxin.