Uremic Toxins

ISBN-13: 9781468454475 / Angielski / Miękka / 2012 / 296 str.

Severin Ringoir; Raymond Vanholder;Shaul G. Massry

Opis

The present book contains the Proceedings of a two day Symposium on Uremic Toxins organized at the University of Ghent in Belgium. A series of guest lectures, free communications and posters have been presented. An international audience of 163 scientists from 16 nationalities listened to and discussed extensively a spectrum of topics brought forward by colleagues and researchers who worked for many years in the field of Uremic Toxins. There is a striking contrast between all the new dialysis strategies available in the work to "clean" the uremic patients and the almost non-progression of our knowledge on uremic toxins in the past decade. In this sense the symposium was felt by all participants as a new start for the research in the biochemical field of the definition of uremia. If the present volume would stimulate new work in this field in order to define uremia, or identify the uremic toxins, the purpose of the organizers would be maximally fulfilled.

Spis treści

Parathyroid Hormone: A Uremic Toxin.- Retention Patterns.- Middle Molecules and the 7 C Factor.- Middle Molecules as a Marker of Uremic Toxins.- The Abiko Factor.- Polyamines and Uremia.- Roles of Hippurate and Indoxyl Sulfate in the Impaired Ligand Binding by Azotemic Plasma.- Hippuric Acid as a Marker.- Suppressive Effect of Quinolinic Acid and Hippuric Acid on Bone Marrow Erythroid Growth and Lymphocyte Blast Formation in Uremia.- Purine Metabolites in Uraemia.- The Role of Lipids in Progressive Glomerular Disease.- Aluminum an Uremic Toxin.- The Insulin-Resistance Inducing Factor Associated with Uremia.- Pathogenesis and Consequences of the Alteration of Glucose Metabolism in Renal Insufficiency.- Separation of Peptidic Inhibitor of Erythropoiesis in Uremia.- Uremic Toxins Inhibit the Platelet Malonyldialdehyde Production Rate.- A Possible Regulatory System of Microtubule Formation Among Uremic Toxins.- Encephalopathic Toxicity: An Experimental Model of Uremia and Solute—Specific Dialysis.- Intellectual Impairment in Chronic Renal Failure.- The Fraction b 4-2: Isolation, Characterization and Biological Activities with Reference to Uremic Polyneuropathy.- Intracellular Acid-Base and Energy Metabolism in Uremia: A Preliminary Study of Five Patients Before and During Dialysis Treatment.- Is Selenium Deficiency the Cause of Uraemic Cardiomyopathy?.- Does Hypermagnesemia Suppress Parathyroid Activity and Therefore Play a Role in Amelioration of Uremic Toxicity?.- Synthesis and Structure-Activity Relationships of Thymopoietin.- The Immunosuppressive Fraction Isolated from Uremic Ultrafiltrates: Attempted Characterization of the Mechanism of Action.- Isolation of an Immunosuppressive Fraction from Uremic Ultrafiltrates.- Binding of Organic Acids to Surface Receptors of Lymphocytes as an Immunosuppressive Mechanism in Uremia.- Uremic Dysmetabolism and its Effect on Immunocompetent and Erythroid Cell Function.- Conversion of Ammonia to Glutamate by L-Glutamic Dehydrogenase, Alcohol Dehydrogenase and NAD+ Immunobilized within Lipid-Polyamide Polyethyleneimine Microcapsules.- A Purification Method by Uncoated Charcoal.- Amino Acid Composition of Uremic Middle and Low Molecular Weight Retention Products.- Biochemical Elucidation and HPLC Fractionation of Fluorescent Peptides in Patients with Chronic Renal Failure.- Separation from Uremic Body Fluids and Normal Urine of Na+, K+-ATPase Inhibitor.- Isolation of Sialylcompounds from Hemofiltrate of Chronic Uremic Patients and Identification by Nuclear Magnetic Resonance.- Identification of Two Uremic toxins by Nuclear Magnetic Resonance and Mass Spectrometry.- Kinetic of Solute Removal in Hemodialysis.- An Advanced, User-Friendly Microcomputer Program for Hemodialysis Kinetics.- Is Serum Urea a Good Index for Predicting Morbidity in Hemodialysis (HD)?.- Predicted time of Dialysis in Patients with Different Volumes of Urea Distribution—The Use of Mathematical Model.- Membranes and their Removal of Uremic Toxins.- Replacement of Excretory Kidney Function by High-Efficiency Hemodiafiltration (HDF) with a Peptide-Permeable Membrane.- Paired filtration-Dialysis (PFD): A Separate Convective-Diffusive System for Extracorporeal Blood Purification in Uraemic Patients.- Removal of Small Proteins—The Stepchild of Dialysis Therapy Protein Permeability of Different Hemofiltration Membranes Analysed by SDS-Poly-acrylamide Gel Electrophoresis (SDS-Page).- Hemofiltration-Induced Serum Modifications in the Pattern of Larger Molecules.- Carnitine Depletion During Chronic Hemodialysisi Effect of Substitution on Free Carnitine Plasma Levels.