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This book presents the process of circulation and adoption of Newtonianism in the Viceroyalty of New Granada (modern-day Colombia) in the eighteenth century by examining José Celestino Mutis’s lectures at the Colegio del Rosario between the 1760s and 1770s. Mostly famous for his botanical activities as director of the botanical expedition, Mutis lectured the first course of mathematics ever created in New Granada on his arrival in Bogota in 1762, in which he included several lectures on physics that encompassed multiple aspects of his interpretation of Newton’s experimental physics.