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ODE/PDE α-Synuclein Models for Parkinson's Disease discusses a mechanism for the evolution of Parkinson's Disease (PD) based on the dynamics of the protein α-synuclein, a monomer that has been implicated in this disease. Specifically, α-synuclein morphs and aggregates into a polymer that can interfere with functioning neurons and lead to neurodegenerative pathology. This book first demonstrates computer-based implementation of a prototype ODE/PDE model for the dynamics of the α-synuclein monomer and polymer, and then details the methodology for the numerical...

This book has a two-fold purpose:

(1) An introduction to the computer-based modeling of influenza, a continuing major worldwide communicable disease.

(2) The use of (1) as an illustration of a methodology for the computer-based modeling of communicable diseases.

For the purposes of (1) and (2), a basic influenza model is formulated as a system of partial differential equations (PDEs) that define the spatiotemporal evolution of four populations: susceptibles, untreated and treated infecteds, and recovereds. The requirements of a well-posed PDE model are...

Mathematical models stated as systems of partial differential equations (PDEs) are broadly used in biology, chemistry, physics and medicine (physiology). These models describe the spatial and temporial variations of the problem system dependent variables, such as temperature, chemical and biochemical concentrations and cell densities, as a function of space and time (spatiotemporal distributions).

For a complete PDE model, initial conditions (ICs) specifying how the problem system starts and boundary conditions (BCs) specifying how the system is defined at its spatial...

Features a solid foundation of mathematical and computational tools to formulate and solve real-world PDE problems across various fields

With a step-by-step approach to solving partial differential equations (PDEs), "Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R "successfully applies computational techniques for solving real-world PDE problems that are found in a variety of fields, including chemistry, physics, biology, and physiology. The book provides readers with the necessary knowledge to reproduce and extend...

Presents the methodology and applications of ODE and PDE models within biomedical science and engineering

With an emphasis on the method of lines (MOL) for partial differential equation (PDE) numerical integration, Method of Lines PDE Analysis in Biomedical Science and Engineering demonstrates the use of numerical methods for the computer solution of PDEs as applied to biomedical science and engineering (BMSE). Written by a well-known researcher in the field, the book provides an introduction to basic numerical methods for initial/boundary value PDEs before...