Mechanisms of Complexation of Ag and Fe Containing Porphyrins with DNA

ISBN-13: 9783659975103 / Angielski / Miękka / 2016 / 104 str.

Safa Aldeen Altaie

Opis

Recently, the interaction of water-soluble porphyrins and metalloporphyrins with DNA has attracted extensive interest, the two basic modes of porphyrin binding to DNA can be used as models for the DNA binding of anticancer drugs. Also, the certain porphyrins are photosensitizers and can be useful in the photodynamic therapy of cancer, this therapy likely depends on the damage caused to DNA during photolysis. At present, the interaction of newly Fe- and Ag-containing porphyrins of different peripheral group with DNA at different media were investigated. The obtained data revealed that thermodynamics and mechanism of complexation can give a physical explanation to the processes that occur in biological systems so - decisively to influence them.

O autorze

Asst. Prof. Dr. Safa Aldeen Abdulla Sulyman Altaie,Dr. Altaie has obtained his Ph.D. degree from Yerevan State University in Biophysical Field, 2010. Currently he is working as a Head of Science department in college of Basic Education in Mosul university, Mosul, IRAQ.