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Cutting-edge researchers describe their efforts to design, synthesize, and evaluate the biological activities of farensyltransferase inhibitors (FTIs); geranylgeranyltransferase inhibitors (GGTIs) are also discussed as potential anticancer drugs. The authors survey in detail such inhibitors as CAAX box peptidomimetics, FPP mimics, and bisubstrate transition state analogs, and critically review their uses in combination with radiation and other cytotoxic agents, such as gemcitabine, cisplatin, and taxanes. Illuminating and richly detailed, Farnesyltransferase Inhibitors in Cancer Therapy...

The Circular Archetype in Microcosm is the culmination of seven years research into the Carved Stone Balls of Late Neolithic Scotland. It is the first study of these enigmatic artefacts since that undertaken by Dorothy Marshall in 1977 and includes all currently known examples in both museums and private hands, described and analysed in considerable detail. For the first time, visual geological characterisation has been undertaken on approximately a third of carved stone balls, which has enabled a more detailed analysis of their potential origin and the landscapes in which they were found....

About the Contributor(s): Lodovico Balducci is a physician, medical oncologist, Senior Member of the Moffitt Cancer Center, and he is Professor of Medicine and Oncologic Science at the University of South Florida in Tampa. He is considered the father of geriatric oncology, a discipline he developed and publicized over the past twenty-five years. He is the senior editor of three textbooks of geriatric oncology and two textbooks of geriatric hematology.

Proceedings of the NATO Advanced Study Institute on Biological Bases of Antisocial Behavior, Il Ciocco, Castelvecchio Pascoli, Italy, September 7-16, 1986