Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies

ISBN-13: 9781588297419 / Angielski / Twarda / 2008 / 472 str.

Richard G. Pestell; Marja T. Nevalainen

Opis

Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. In, Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies, the authors focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art title provides key insights into cutting edge advances in prostate cancer research, such as laparoscopic radical prostatectomy, and offers a critical evaluation and discussion of opportunities for development of novel therapies for prostate cancer. Clinical trials that have not been covered or evaluated in any other books currently available are also discussed. Invaluable to physicians and researchers, Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies provides a comprehensive translational resource as well as an important source of information for prostate cancer patients. "

Recenzje

From the reviews:

"In this detailed and up-to-date book, leaders in prostate cancer research review the current knowledge of genetic pathways and major molecular aberrations involved in prostate cancer as well as the treatment of the disease. ... The figures and tables are clear and provide essential additional information. ... the editors and authors have succeeded in clearly summarizing the most important recent advances in prostate cancer research, and the book will interest urologists, medical oncologists, and prostate cancer researchers." (Joost L. Boormans, The New England Journal of Medicine, August, 2008)

Spis treści

1. Histopathology and Molecular Biology of Prostate Atrophy: A Lesion Associated with Inflammation, PIN, and Prostate Cancer 2. Epigenetic Gene Silencing in Prostate Cancer 3. Inherited Genetic Changes in Prostate Cancer 4. Prostate Molecular Oncogenesis: Gene Deletions and Somatic Mutations 5. Somatic Genetic Changes in Prostate Cancer: Androgen Receptor Alterations 6. Androgen Receptor in Prostate Cancer Progression 7. Epigenetic Modification and Acetylation of Androgen Receptor Regulate Prostate Cellular Growth 8. Estrogen Receptor Alpha and Beta in the Regulation of Normal and Malignant Prostate Epithelium 9. Estrogen Action in Normal Prostate Epithelium and in Prostate Cancer 10. Hypoxia Inducible Factor 1 and Angiogenesis in Prostate Cancer 11. Signal Transduction by the Ras – MAP Kinase Pathway in Prostate Cancer Progression 12. Transcription Factors Stat5 and Stat3: Survival Factors for Prostate Cancer Cells 13. Role of PI3K-Akt and PTEN in the Growth and Progression of Prostate Cancer 14. New Perspectives in Prediction of Clinical Outcome of Prostate Cancer: TMPRSS2-ETS Gene Fusion in Prostate Cancer 15. New Directions in Radiation Therapy of Prostate Cancer: Brachytherapy and Intensity Modulated Radiation Therapy 16. Advances in Surgical Intervention of Prostate Cancer: Comparison of the Benefits and Pitfalls of Retropubic, Perineal and Laparoscopic Radical Prostatectomy 17. Targeted Therapy Trials for Prostate Cancer 18. New Perspectives on Chemotherapy of Prostate Cancer 19. Concluding Remarks: The Future of Prostate Cancer