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In this issue, Guest Editors Pratik Panharipande and Wesley Ely look at modern Sedation techniques in the critically ill. Topics include: -Pharmacology of commonly used sedatives and analgesics in the ICU,- -Pharmacology of newer agents for sedation and analgesia in the critically ill,- -Current sedation practices: lessons learned from recent international surveys,- -Sedation and Immunomodulation,- -Sedation and sleep disturbances in the ICU,- and more

In this issue of Anesthesiology Clinics, Guest Editors Pratik Panharipande and Wesley Ely look at modern sedation techniques in the critically ill. Topics include pharmacology of commonly used analgesics and sedatives in the ICU (including benzodiazepines, propofol, and opioids); pharmacology of sedative-analgesic agents (including dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists); lessons learned from international surveys of current sedation practices; protocolized and target-based sedation and analgesia in the ICU; sedation and...