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This new volume of Methods in Cell Biology looks at methods for lysosomes and lysosomal diseases. Chapters focus upon practical experimental protocols to guide researchers through the analysis of multiple aspects of lysosome biology and function. In addition, it details protocols relevant to clinical monitoring of patients with lysosomal diseases. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come.

• Covers sections on model systems and functional studies, imaging-based approaches and emerging studies
• Chapters...

Problems with cellular lysosome function underlie a group of neurological disorders known as the storage diseases. These are inherited disorders, characterized by a failure to control the accumulation of internal cell products resulting in cell death. In recent years major advances in the fields of biochemistry and cell biology have expanded our understanding of these disorders. This book describes the molecular mechanisms and pathophysiological pathways involved and the potential for interventions aimed at treatment.