Iodine and the Brain

ISBN-13: 9781461280712 / Angielski / Miękka / 2012 / 380 str.

G. Robert DeLong; Jacob Robbins;Peter G. Condliffe

Opis

This volume contains the proceedings of a conference held at the National Institutes of Health in Bethesda on March 21-23. 1988. jointly sponsored by the International Council for Control of Iodine Deficiency Disorders (ICCIDD) and the Fogarty International Center of the National Institutes of Health. Several themes converged to make this meeting timely. The first is an increasing awareness of iodine deficiency disorders as a world-wide problem of public health and a preventable cause of mental deficiency. and as a subject of scientific effort. Increased interest in these problems owes a great deal to accessibility to remote and under developed areas of the world where iodine deficiency persists. As with any subject. greater scrutiny yields unexpected complexity and interest. It is true that provision of iodine. typically as iodized salt, is the necessary and sufficient preventative for iodine deficiency disorders. without including endemic cretinism. This provision is a governmental, economic and social problem. Apart from this, however, the scientific and medical problem of iodine deficiency and its effect on brain development and function is one of great interest and importance for developmental neurology and psychology. Even though the specific preventative agent is known, we do not totally understand the neurobiological questions raised."

Spis treści

Iodine and the Brain.- MOLECULAR BIOLOGY OF IODINE AND THYROID HORMONES IN THE BRAIN.- Regulation of Thyroid Hormone Metabolism in the Brain.- Thyroid Hormone Receptor Related mRNAS.- A Neural Thyroid Hormone Receptor Gene.- Thyroid Hormone Transport from Blood into Brain Cells.- Thyroid Hormone Control of Brain Develpment.- Thyroid Hormone Receptors in the Developing Brain.- Thyroid Hormone Regulation of Specific mRNAS in the Developing Brain.- Thyroid Influences on the Developing Cerebellum and Hippocampus of the Rat.- Quantitative Studies of the Effects of Hypothyroidism on the Development of the Cerebral Cortex.- Microtubule Assembly: Regulation by Thyroid Hormones.- Investigation of Myelinogenesis in Vitro: Transient Expression of 3,5,3’-Triiodothyronine Nuclear Receptors in Secondary Cultures of Pure Rat Oligodendrocytes.- Developmental and Thyroid Hormone Regulation of Na,K-ATPase Isoforms in the Brain.- Thyroid Hormones and Neurotransmitter Systems: An Interaction with Nerve Growth Factor in the Regulation of Cholinergic Neurons.- Ontogeny of Thyroid Hormone-Processing Ssytems in Rat Brain.- The Fetus and Iodine Deficiency.- Development of Fetal Thyroid System Control.- The Fetus and Iodine Deficiency: Marmoset and Sheep Models of Iodine Deficiency.- Models of Fetal Iodine Deficiency.- Screening for Congenital Hypothyroidism: Beneficial Effects on Neuropsychological Development.- Placental Deiodination of the Thyroid Hormones.- Human Studies of Iodine Defiiency, Endemic Cretinism and Psychomotor Function.- Endemic Cretinism: An Overview.- Observations on the Neurology of Endemic Cretinism.- Neurological Aspects of Cretinism in Qinghai Province.- Influence of Iodine Deficiency on Human Fetal Thyroid Gland and Brain.- Neuropsychological Studies in Iodine Deficiency Areas in China.- Iodine Deficiency: Implications for Mental and Psychomotor Development in Children.- Early Correction of Iodine Deficiency and Late Effects on Psychomotor Capabilities and Migration.- Field and Experimental Studies of Iodine Deficiency in Spain.- Iodine Deficiency, Maternal Thyroxine Levels in Pregnancy and Developmental Disorders in the Children.- Maternal Thyroid Hormones and Fetal Brain Development.- Free Sessions.- A Collection of Abstracts Presented during Evening Sessions.