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This book presents a comprehensive optimization-based theory and framework that exploits the synergistic interactions and tradeoffs between process design and operational decisions that span different time scales. Conventional methods in the process industry often isolate decision making mechanisms with a hierarchical information flow to achieve tractable problems, risking suboptimal, even infeasible operations. In this book, foundations of a systematic model-based strategy for simultaneous process design, scheduling, and control optimization is detailed to achieve reduced cost and improved...