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Bacteriocins are therapeutic, biocontrolling and proteinaceous molecules produced by various lineages of bacteria. It is synthesized under the control of genetic mechanisms and develops their lethal action on the microbial cell by multiples mechanisms. In this study we evaluated the evolutionary relationship between bacteriocin producing gram positive and gram negative bacteria and modeling of their protein molecules. To find out these phylogenetic trees were constructed on the basis of homology between the protein sequences. Phylogenetic tree for gram negative sequences shown medium...