Role of Tcf in Body Axis Formation

ISBN-13: 9783838320526 / Angielski / Miękka / 2010 / 80 str.

Miranda Molenaar

Opis

A novel role of TCF family in body axis formation. Revolutionary high impact discoveries are described, elucidating the missing link in the Wnt pathway and protein-TCF combinations with dual functions. By studying the primary axis formation of Xenopus laevis, it was firstly shown that, in combination with beta-catenin, TCF acts as a potent activator of proto-oncogenes. Secondly, it was discovered that in combination with the Groucho family of proteins, TCF acts as suppressor of oncogene transcription. Stronlgy suggesting that TCF controls oncogene transcription in a dual fashion. These discoveries contributed to the origination of a major area of cancer research and opened multiple angles for cancer therapy development.

O autorze

Miranda Molenaar was born in the Netherlands. She studied Medical Biology at the Utrecht University. She investigated the mechanism of body axis formation, documented in this thesis and leading to a PhD. degree in March 2000. Since then, she is active in the biopharmaceutical industry, contributing to the development of antibody based therapy.