Peyer's Patches Nanoimmunoresponse Using Organosilica Particles

ISBN-13: 9783659120152 / Angielski / Miękka / 2012 / 152 str.

Aziz Awaad; Michihiro Nakamura; Kazunori Ishimura

Opis

Peyers patches have a potential role not only in the mucosal but also in the systemic immune responses against pathogens. Recently, Peyers patches and their immune cells are important to be targeted with proteins or antigens for nanobiology and nanomedicine applications. Nanoparticles have several advantages as good models for vaccine delivery. Nanoparticles uptake by Peyers patches introduces the possibility of accommodate vaccines for oral immunization. Particle size is one of the most important factors in the uptake and pathway of nanoparticles into the gastrointestinal tract especially Peyers patches. In this work, thiol-organosilica particles have characteristics such as controllable size, surface charge (approximately -50 mV), mucoadhesive and possess surface mercaptopropyl residues containing alkyl chains and thiol residues. These factors might be optimal for studying vaccine delivery and the immunological interactions between particles size and immune cells such as M cells of Peyers patches and plasma cells of villi lamina propria. This work introduces important information of the peyers patches immune responses using different sizes of organosilica particles.

O autorze

Acadimic Job: Lecturer at Sohag University, Faculty of Science, Zoology Department, Sohag, Egypt; Research Interests: Peyer's Patches Histology and Histochemistry, Nanoparticles based Immune Responses (Nanoimmunoresponses) at Gastrointestinal Tract.