Small Interference RNA (SiRNA) Mediated Gene Silencing

ISBN-13: 9786139854837 / Angielski / Miękka / 2018 / 64 str.

Toyfiquz Zaman; Md. Rezanur Rahman; A.K.M Nazmul Huda

Opis

Small interfering RNA (siRNA) is yet a developing field in molecular biology and has unfolded as a novel post transcription gene silencing strategy which has therapeutic potentiality. Indeed They have been shown to play a vital role in a wide range of biological process. They regulate the expression of a larege number of mRNAs. The gene silencing mediated by this small RNA (siRNA) a major component of gene regulation during various developmental and physiological processes. The accumulating knowledge about their biogenesis and gene silencing mechanism will add a new dimension to our understnding about the complex gene regulatory networks. Every gene in human genome to a some extent contributing to a disease is amenable to regulation with siRNA, therefore opening an unprecedented opportunities for drug discovery. Besides the well established role for siRNA as a tool for target screening and validation in vitro, recent progress of siRNA delivery in vivo raised expectations for siRNA drugs as the up-and-coming 'magic bullet'. Whether siRNA compounds will make it as novel chemical entities from 'bench to bedside' will probably depend largely on improving their pharmaco kinetics in term

O autorze

Zaman, Toyfiquz
Toyfiquz Zaman is currently Lecturer at the Department of Biochemistry and Biotechnology in Khwaja Yunus Ali University, Sirajgong, Bangladesh. He completed Bachelor of Science with Honours and Master of Science in Biotechnology and Genetic Engineering from Islamic University, Kushtia, Bangladesh.