Serum levels of soluble RANKL in patients with DISH and AS

ISBN-13: 9783659577598 / Angielski

Mariela Geneva-Popova; Stanislava Popova

Opis

S-RANKL has been identified to control bone regeneration and remodeling. Methods: S-RANKL is estimated on 55 patients with Diffuse Idiopathic Skeletal Hyperostosis (DISH), 25 patients with Ankylosing Spondilitis (AS), 50 patients with spondylosis and 15 particularly healthy people aged 55-65. The measuring of the S-RANKL is done by LISA-method Results:The average measurements of s-RANKL of patients with DISH were 197,00±35,90 pg/ml, in patients with AS 190,86±18,54 pg/ml. S-RANKL in patients with spondilosis were 20,60±66,16 pg/ml, and in old control group were 23,33±15,07 pg/ml. The average measurements of s-RANKL in patients with DISH and AS were significant higher in comparison with the results of patients with spondylosis and healthy people, regardless of their age (p0.05). Conclusion: S-RANKL is significantly increased in patients with DISH and spondylosis in comparison with the results of patients with AS and healthy old people. Hypothetically, this might be a result as a sequence of events, based on stimulation of inflammatory proteins, on-going osteoporosis and compresion fractures in patients with DISH and spondylitis.

O autorze

Geneva-Popova, Mariela
Assoc. Prof Mariela Geneva-Popova graduated in medicine in 1991 and has recognized 3 specialties - rheumatology, internal diseases, infectious diseases and professional specialization applied psychology and psychotherapy, Master in Health Management. She has worked as a lecturer at the Medical University, Plovdiv since 1998.