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Mutations in the BRCA1/2 genes are the most common cause of hereditary breast and ovarian cancer (HBOC), and HBOC is an autosomal dominant cancer predisposition syndrome. Individuals with HBOC have a high risk for breast and ovarian cancers and a moderate risk for other cancers, such as prostate, pancreatic, melanoma, and fallopian tube cancers. The goal of screening individuals at high risk of familial cancer is either prevention (such as a change in lifestyle or diet) or early detection of cancer. The identification of BRCA mutation carriers is important, since increased surveillance, drug...

In recent years, there has been substantial development in breast cancer research and its clinical applications, for example, breast cancer biology and genomics, epidemiology and prevention, early detection and screening, and diagnosis and treatment. As such, this book consolidates recent advances in breast cancer biology and therapeutics, covering a broad spectrum of interrelated subjects. Chapters cover topics such as pathobiology of breast cancer, biomarkers, in vitro models of breast cancer, pharmacotherapy, screening and management, diagnostic imaging, and more. This book is a valuable...