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Over the last decade, the considerable progress made in biochemistry, molecular biology, genetics and neuropharmacology has revealed some ofthe intimate mechanisms ofthe neurodegenerative disorders. There is increasing evidence linking genetic defects affecting mitochondria to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease and some other neurological disorders. Advances in knowledge are fueled through improved animal models that use mitochondrial toxins, excitotoxins, and transgenic animals. Therapeutic studies in these models have strengthened...

Focuses on the metabolism, analytical chemistry and role of kynurenine metabolites in different disorders of the central nervous system. This book discusses neurodegenerative models and pharmacological investigations with kynurenine metabolites and possibl

Over the last decade, the considerable progress made in biochemistry, molecular biology, genetics and neuropharmacology has revealed some ofthe intimate mechanisms ofthe neurodegenerative disorders. There is increasing evidence linking genetic defects affecting mitochondria to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease and some other neurological disorders. Advances in knowledge are fueled through improved animal models that use mitochondrial toxins, excitotoxins, and transgenic animals. Therapeutic studies in these models have strengthened...