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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of two volumes on endosome signaling and includes chapters on such topics as measurement of entry into the endosomal compartment by multi-parametric image analysis, assessment of peptide internalization and endosomal signaling, and VEGF-A in endosomal signaling.

• Continues the legacy of this premier serial with quality chapters authored by leaders in the field
• Covers endosome signaling
• Contains...

A succession of ruthless men have seized power in the wake of Genghis Khan's death--all descendants of the great leader, but none with his indomitable character. One grandson, Guyuk, strains the loyalties of the tribes to the breaking point, and another, Mongke, brutally eliminates the opposition and dispatches his younger...

John Lee Johnson has a way of getting things done--but now he needs to get things done on his own 50,000-acre ranch in Texas. Two gangs of rustlers have been slowly draining the cattle from his herd, and that could spell the end of his livelihood.

He begins the journey from Ohio back to Texas outfitted with military holsters around his waist holding Navy Colts and two more stuck in his belt. He knows how to use them and use them well. Before he can complete the trip, however, the Union government asks him to arrest two outlaws hiding in the badlands of the nation.

But Johnson...

• Continues the legacy of this premier serial with quality chapters authored by leaders in the field
• Covers G protein coupled receptors
• Contains chapters...

With help from his attorney, former Brigadier General Frank McGrew has somehow managed to walk away from countless charges that include extortion, murder, and brutality of Confederate prisoners. Now, he is determined to murder every man who has been involved in his downfall. As he scrawls out a list of his intended targets that include his ever-present nemesis Levi Brown, McGrew's eyes focus on the first name: John Lee Johnson. With a gang of hellions already assembled, McGrew is ready to seek justice.

As McGrew begins his killing spree, the government discovers he has plans to...

From the author of the bestselling The Dangerous Book for Boys

The Great Khan is dead--and his vast empire, forged through raw courage, tactical brilliance, and indomitable force, hangs in the balance. Now, with the sons of Genghis Khan maneuvering for supremacy, the very qualities that united the fierce Mongol tribes threaten to tear them apart.
Genghis's tough and canny heir, Ogedai, is on the verge of becoming the new Khan. Inexplicably, Ogedai has delayed his coronation to complete a project many deem a folly: the building of Karakorum, a magnificent...