Role of PPAR agonist in Cerebral Ischemia Reperfusion Injury : Effect of PPAR agonist on I/R injury

ISBN-13: 9783659264351 / Angielski / Miękka / 2012 / 136 str.

Jitendra Vaghasiya; Krunal Mangukia

Opis

Objective: Present study was designed to investigate effect of gemfibrozil on I/R. Experimental: I/R in rats were induced by bilateral carotid artery occlusion (30 min) and followed by reperfusion (2 hrs). Results and Discussion: Gemfibrozil treated rats demonstrated significant reduction in infarct sizes (P 0.05) when compared with I/R group of rats, suggested that gemfibrozil markedly attenuated I/R injury. Gemfibrozil treatment demonstrated a significant decreased in malondialdehyde (P 0.01), and significant increased was observed in level of reduced glutathione (P 0.01), superoxide dismutase (P 0.05) and catalase (P 0.01). Gemfibrozil treatment resulted significant increased in level of Na+-K+ ATPase (P 0.05) and Mg+2 - ATPase (P 0.01) and significant reduction of Ca+2 - ATPase (P 0.01) when compared with I/R group of rats. Conclusion: In conclusion, gemfibrozil attenuated the cerebral ischemia reperfusion injury and prevention is being shown via membrane stabilization, reducing the oxidative stress, and preventing apoptotic cell death.

O autorze

Dr. Jitendra D. Vaghasiya, Associate Professor of Pharmacology. His major area of research is related to cardiovascular complication associated with dyslipidemia and diabetes in animal models. He has a credit of 35 peer reviewed papers in reputed journals and 30 published abstracts. He is also a manuscript reviewer of number of major journals.