PART ONE ESSENTIAL CONCEPTS OF PATHOPHYSIOLOGY 14 Introduction to clinical science 15 Homeostasis 16 Cellular structure and function 17 Altered cellular function 18 Genes PART TWO ALTERATIONS TO REGULATION AND CONTROL 19 The structure and function of the neurological system 20 Pain 21 Concepts of neurological dysfunction 22 Alterations of neurological function across the life span 23 The structure and function of the endocrine system 24 Alterations of endocrine function across the life span PART THREE ALTERATIONS TO PROTECTION AND MOVEMENT 25 The structure and function of the immune system 26 Inflammation and fever 24 Infection 25 Alterations of immune function across the life span 26 The structure and function of the haematological system 27 Alterations of haematological function across the life span 28 The structure and function of the integumentary system 29 Alterations of the integumentary system across the life span 30 The structure and function of the musculoskeletal system 31 Alterations of musculoskeletal function across the life span PART FOUR ALTERATIONS TO BODY MAINTENANCE 32 The structure and function of the cardiovascular and lymphatic systems 33 Alterations of cardiovascular function across the life span 31 The structure and function of the pulmonary system 32 Alterations of pulmonary function across the life span 33 The structure and function of the digestive system 34 Alterations of digestive function across the life span 35 The structure and function of the urinary system 36 Fluids and electrolytes, acids and bases 37 Alterations of renal and urinary tract function across the life span PART FIVE ALTERATIONS TO CONTINUITY 34 The structure and function of the reproductive systems 35 Alterations of the reproductive systems across the life span PART SIX CONTEMPORARY HEALTH ISSUES 36 Introduction to contemporary health issues 34 Stress and chronic disease 39 Obesity 40 Type 2 diabetes 41 Cancer 42 Genes, genetic diseases and the environment 39 Neurobiology of mental illness 42 Indigenous health issues in Australia 43 Maori health in Aotearoa New Zealand