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In 1803, when the United States purchased Louisiana from France, the great expanse of this new American territory was a blank--not only on the map but in our knowledge. President Thomas Jefferson keenly understood that the course of the nation's destiny lay westward and that a national "Voyage of Discovery" must be mounted to determine the nature and accessibility of the frontier. He commissioned his young secretary, Meriwether Lewis, to lead an intelligence-gathering expedition from the Missouri River to the northern Pacific coast and back. From 1804 to 1806, Lewis, accompanied by co-captain...