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This RRCR-conference-volume marks "number six" in a 20-year evolution of international conferences on the adjuvant therapy of primary breast cancer. Starting in 1978, a handful of some 80 en- thusiastic breast cancer surgeons and oncologists, met in a se- cluded mountain resort near st. Gallen in Eastern Switzerland, to exchange their early data of some pioneer trials on adjuvant sys- temic therapy of early breast cancer, and to correlate their future research efforts to overcome the frustrating prognostic stagna- tion of this dominant neoplastic disease in Western females dur- ing the past...