Perfusion Cell Culture Processes for Biopharmaceuticals: Process Development, Design, and Scale-Up

ISBN-13: 9781108480031 / Angielski / Twarda / 2020 / 216 str.

Massimo Morbidelli; Moritz Wolf; Jean-Marc Bielser

Opis

Master the design and operation of perfusion cell cultures with this authoritative reference.

Recenzje

'A delightful guide full of important information for those of us who want to make perfusion great again thanks to the appearance of new cell retention technologies, single use bioreactors and sensors. It will greatly help biotech developers to better understand the fundamentals of cell culture in perfusion, to design appropriately their systems and to control optimally their processes in order to deliver high quality product at a better cost efficiency than the classical large-scale fed-batch processes.' Hervé Broly, Biotech Process Sciences

Spis treści

1. Perfusion mammalian cell culture for recombinant protein manufacturing; 2. Perfusion bioreactors; 3. Scale-down models and sensors for process development; 4. Design and optimization of mammalian cell perfusion cultures; 5. Clinical and commercial-scale reactors; 6. Mechanistic and statistical modeling of bioprocesses.