Wyniki wyszukiwania:

This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead...

The articles in this collection cover the region extending from Italy to the Black Sea and to Egypt, over a period of seven centuries, with an emphasis on the considerable economic and social interaction between the West and the regions of the Eastern Mediterranean. They represent key works in the oeuvre of David Jacoby, the doyen of scholars in the field over many decades.

In an elegant exposition informed by many years of helping people to understand feelings of shame, leading Jungian analyst Mario Jacoby provides a timely and comprehensive exploration of the many aspects of shame and shows how it occupies a central place in our emotional experience. Jacoby shows a lack of self-esteem is often at the root of excessive shame. As well as providing practical examples of how therapy can help, Jacoby draws upon a wealth of historical and cultural scholarship to show how important shame is for us in both its individual and social aspects. This Classic Edition of...

• Umfassende Kommentierung der 631-651 BGB
• Erlauterung der Gewahrleistung nach der VOB/B
• Informationen zu BauFordSiG, insolvenzrechtliche Bezugen und zum Bautragervertrag
• Ausfuhrung zu Gewahrleistung/Haftung des Architekten und anderer Sonderfachleute
• Erorterung praxisrelevanter Fragen zur Abtretung von Gewahrleistungsanspruchen
• Ausfuhrungen zur Haftung der Parteien untereinander/Ausgleich bei gemeinschaftlicher Haftung gegenuber Dritten
  

"In der Philosophie der Gegenwart fehlt es an einem systematischen Lehrbuche uber die verwickelten Strukturverhaltnisse, die unseren alltaglichen und wissenschaftlichen Wirklichkeitsbegriffen zu Grunde liegen. Das vorliegende Buch versucht, diese Lucke auszufullen. Dem umfassenden Feld seiner Aufgabe entsprechend wendet es sich nicht nur an den engeren Kreis der Fachphilosophen, sondern zugleich an den weiteren Kreis aller derjenigen, denen der Wirklichkeitsbegriff ihres Arbeitsgebietes ein Problem ist." "(Aus dem Vorwort zu Band I)"

Der Greifswalder Philosophieprofessor Gunther Jacoby...