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Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor.

Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated...

Organized crime in America today is not the tough hoodlums familiar to moviegoers and TV watchers. It is more sophisticated, with many college graduates, gifted with organizational genius, all belonging to twenty-four tightly knit -families, - who have corrupted legitimate business and infiltrated some of the highest levels of local, state, and federal government. Their power reaches into Congress, into the executive and judicial branches, police agencies, and labor unions, and into such business enterprises as real estate, retail stores, restaurants, hotels, linen-supply houses, and...

Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor.

Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated...

One of the most admired American poets of his generation, James Wright (1927-80) wrote contemplative, sturdy, and generous poems with an honesty, clarity, and stylistic range matched by very few--then or now. From his Deep Image-inspired lyrics to his Whtimanesque renderings of Neruda, Vallejo, and other Latin American poets, and from his heartfelt reflections on life, love, and loss in his native Ohio to the celebrated prose poems (set frequently in Italy) that marked the end of his important career, Above the River gathers the complete work of a modern master. It also features a...

James Mill was the consummate utilitarian economist and theorist: his numerous intellectual interests and practical pursuits shatter the net boundaries of modern specialist scholarship in social science.

Mill's many-sided genius was primarily a product of the age in which he lived. The late eighteenth and early nineteenth centuries saw a remarkable flowering of intellectual genius in Scotland in all of the arts and sciences, which gave the country a leading place in the broad European movement known as the Enlightenment, Mill being in fact only one of many brilliant men Scotland...