Co-Signal Molecules in T Cell Activation: Immune Regulation in Health and Disease

ISBN-13: 9789813297197 / Angielski / Miękka / 2020 / 326 str.

Miyuki Azuma; Hideo Yagita

O autorze

Miyuki Azuma

Tokyo Medical and Dental University, Grad Sch of Medical and Dental Sciences, Japan

Hideo Yagita

Juntendo University School of Medicine, Dept of Immunology, Japan  

Blurb

This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.