Genetics of the Epilepsies

ISBN-13: 9783642955556 / Angielski / Miękka / 2012 / 215 str.

Gertrud Beck-Mannagetta; V. Elving Anderson; Hermann Doose

Opis

This book provides neurologists, geneticists, pediatricians, and pharmacologists with basic knowledge for genetic counselling, while putting emphasis on the evidence of heterogeneity in this field. The volume contains separate sections on population rates, family studies on selected syndromes, and special methods and topics. Two particularly topical questions concern the prospective evaluation of morbidity risk for seizures in offspring of epileptic patients and the relationship of pharmacogenetics to epilepsy. The book aims to stimulate communication across traditional disciplinary lines and to further collaborative research.

Spis treści

Opening Address.- Population Rates of Epileptic Seizures and Epileptic Syndromes.- Epidemiologic Measurements for the Determination of Genetic Risks.- Clinical Syndromes of Epilepsy.- Epilepsies and Epileptic Syndromes in a Neurological Seizure Clinic.- Family Studies on Selected Syndromes.- Genetic Analysis of Febrile Convulsions: Twin and Family Studies.- Absences.- Family Studies on the Genetics of Juvenile Myoclonic Epilepsy (Epilepsy with Impulsive Petit Mal).- Segregation Analysis of Juvenile Myoclonic Epilepsy.- Is Juvenile Myoclonic Epilepsy Polygenic?.- Benign Epilepsy of Childhood with Centro-temporal Spikes.- Genetics of the Partial Epilepsies.- Genetics of EEG-Characteristics.- Genetic Variation of the Normal Human EEG.- Generalized Spikes and Waves.- Photosensitivity.- Morbidity Risk in Offspring.- Genetic Risks in Offspring of Epileptic Parents.- Morbidity Risk for Seizures and Epilepsy in Offspring of Patients with Epilepsy.- Generalized Spike and Wave Paroxysm — Subclinical Signs of Seizure Liability in Offspring of Epileptic Patients.- Febrile Convulsions, Epileptic Seizures and EEG Abnormalities in Offspring of Epileptic Mothers.- Special Methods.- Twin Studies in Epilepsy.- HLA and Epilepsy.- Plasma Amino Acid and Genetic Studies in Epilepsy.- Special Topics.- Genetic Variability in Fetal Response to Anticonvulsants.- Experimental Neurogenetics of the Epilepsies.- Perspectives: Clues in Mapping Epilepsy Genes.- Closing Remarks.

O autorze

Dieter Janz, em. Ordinarius für Neurologie der Freien Universität Berlin, Mitherausgeber der Gesammelten Schriften Viktor von Weizsäckers.