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Polymeric scaffolds provide a surface that can facilitate cell growth and tissue morphogenesis. Of particular interest is the role of nanoscale materials on cell behavior. Nanoscale topographies can be generated on two-dimensional polymeric substrates via reactive ion etching. The magnitude and morphology of the topography can be tailored by the gas media, etching time and power used. Cellular morphology, adhesion and differntiation can be controlled by altering the magnitude surface topography. The results suggest that cells can detect nanoscalar 2D surface topographies and alter ...