Human Aging: From Cellular Mechanisms to Therapeutic Strategies

ISBN-13: 9780128225691 / Angielski / Miękka / 2021

Calogero Caruso; Giuseppina Candore

Recenzje

"The articles are all in English and mostly written by Italian specialists in medical and social aging work. The chapters cover evolution demographics, pathobiology (age-related diseases), cellular senescence, inflammatory chronic diseases, reactive oxygen species, aging and the im>mune system, vaccination in the aged, hormesis, sarcopenia, hormonal changes in aging, chronobiology, cognitive decline, lifestyle modulation, nutritional biomarkers for aging, cytomegalovirus infection, ethics of aging, and fighting age-related diseases.

Those who teach courses on aging or death and dying may want to supplement these informative chapters with readings on longevity studies among the 92 phyla. The editors asked the participants writing these chapters to provide about five or six pages of references for each topic that will greatly help anyone doing research in these fields." --The Quarterly Review of Biology

Spis treści

1. Aging and longevity: An evolutionary approach
2. Demographic aspects of aging
3. Pathobiology of aging: An introduction to age-related diseases
4. Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process
5. The role of inflammaging in the development of chronic diseases of older people
6. A new perspective on ROS in aging with an integrated view of the gut microbiota
7. Aging of immune system
8. Vaccination in old age: Challenges and promises
9. Resilience signaling and hormesis in brain health and disease
10. Different components of frailty in the aging subjects-The role of sarcopenia
11. Hormones in aging
12. Chronobiology and chrononutrition: Relevance for aging
13. Nutraceutical approach to age-related diseases-The clinical evidence on cognitive decline
14. Ways to become old: Role of lifestyle in modulation of the hallmarks of aging
15. Nutritional biomarkers in aging research
16. The role of cytomegalovirus in organismal and immune aging
17. Ethics of aging
18. Conclusions. Slowing aging and fighting age-related diseases, from bench to bedside?