Lymphocytic Choriomeningitis Virus and Other Arenaviruses: Symposium Held at the Heinrich-Pette-Institut Für Experimentelle Virologie Und Immunologie,

ISBN-13: 9783540064039 / Angielski / Miękka / 1973 / 342 str.

Fritz Lehmann-Grube

Opis

Four decades ago, lymphocytic choriomeningitis virus was discovered, at about the same time and independently, in 3 different localities in the U.S.A. Armstrong and Lillie encountered the agent in a monkey when they passaged a recent isolate of the St. Louis encephalitis virus; Rivers and Scott isolated 5 strains from patients with meningitis; and Traub revealed the virus in a colony of albino mice. Already in these first isolations mice were incriminated, and later observa- tions proved beyond doubt that M. musculus is the principal reservoir of the virus in nature. For some time LCM virus was regarded as the sole etiologic agent of Wallgren's "meningite aseptique aigue." Soon, however, it became clear that Wallgren's syndrome had a multitude of causes, among which the LCM virus was of little relevance, and in subsequent years it disappeared from the sight of most viro- logists. Indeed, it might have fallen into oblivion had it not been for Erich Traub who, practically all by himself, continued to investigate the intricate relationship between this virus and its natural host, the common house mouse.

Spis treści

General Introduction.- LCM Virus Research, Retrospect and Prospects.- Lymphocytic Choriomeningitis Virus.- The Virus: Purification, Chemical and Physical Properties, Complement-Fixing Antigen (s).- LCM Virus: Its Purification and its Chemical and Physical Properties.- Antigenic Properties of the LCM Virus: Virion and Complement-Fixing Antigen.- Electron Microscopy of LCM Virus-Infected L Cells.- Interaction of LCM Virus with Cells, Including New Virus-Induced Cellular Antigens.- Antigenic Alteration of Cells in Vitro Infected with LCM Virus.- In Vitro Correlates of LCM Virus-Induced Immune Response.- Histocompatibility and Lymphocytic Choriomeningitis Virus Infection.- Persistent Infection in Vitro and in Vivo, Including Interference Phenomena.- Cyclical Transient Infection, An Explanation of Persistent Virus Infection.- Plaque Assays and Current Concepts of Regulation in Arenavirus Infections.- Inapparent Infection of Syrian Hamsters with the Virus of Lymphocytic Choriomeningitis.- Congenital LCM Virus Infection in “Germ-Free” Haas Strain Mice.- LCM Virus-Induced Hemopoietic Disorder in Mice and its Role in the Induction of Tolerance.- Murine LCM Virus Infection: Tolerance and Immunity.- Inhibition of Mouse Tumors and Viruses by the M-P Strain of LCM Virus.- Acute and Chronic LCM Disease in Man and Animals.- Acute and Chronic LCM Disease.- On the Pathogenesis of LCM Disease: Effects of Immunosuppression with Anti-Lymphocyte Serum.- Thymus-Dependent (T) Cell Competence in Chronic LCM Virus Infection.- Pathogenesis of LCM Disease in the Rat.- In Vitro Measurement of the Time Course of Cellular Immunity to LCM Virus in Mice.- LCM Disease of the Adult Rat: Morphological Alterations of the Brain.- Epidemiologic Aspects of Lymphocytic Choriomeningitis in Man.- Other Arenaviruses.- Hemorrhagic Fever Group.- Biology of Tacaribe-Complex Viruses.- Biophysical and Biochemical Studies of Pichinde Virus.- Ultrastructural Studies of Arenaviruses.- Tamiami Virus-Induced Immunopathological Disease of the Central Nervous System.- The Pathogenesis of Tamiami Virus Meningoencephalitis in Newborn Mice.- Behavior of Machupo and Latino Viruses in Calomys callosus from Two Geographic Areas of Bolivia.- Lassa Fever Virus.- Lassa Fever Virus.