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Man can only tolerate a limited range of environmental conditions, whereas other lifeforms thrive in the most intense conditions - in extreme heat or many, many leagues under the sea in utter darkness or deep in the middle of rocks. Why is this so?

Can someone really die of fright? How do cocaine, LSD and morphine work? Why do chilli peppers taste hot? This book reveals the secrets of ion channels, which produce the electrical signals in our cells.

The challenge of scaling the highest mountain, exploring the deepest ocean, crossing the hottest desert, or swimming in near-freezing water is irresistible to many people. Life at the Extremes is an engrossing exploration of what happens to our bodies in these seemingly uninhabitable environments. Frances Ashcroft weaves stories of extraordinary feats of endurance with historical material and the latest scientific findings as she investigates the limits of human survival and the remarkable adaptations that enable us to withstand extreme conditions.
What causes mountain sickness?...

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.

Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular...