Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization

ISBN-13: 9783030115951 / Angielski / Twarda / 2019 / 306 str.

Fatma N. Kok; Ahu Arslan Yildiz; Fatih Inci

Spis treści

Chapter1: Structural and mechanical characterization of supported model membranes by AFM.- Chapter2: To image the orientation and spatial distribution of reconstituted Na+,K+-ATPase in model lipid membranes.- Chapter3: Asymmetric Model Membranes: Frontiers and Challenges.- Chapter4: Modelling of Cell Membrane Systems.- Chapter5: Molecular Dynamics Studies of Nanoparticle Transport Through Model Lipid Membranes.- Chapter6: Investigation of Cell Interactions on Biomimetic Lipid Membranes.- Chapter7: Tethered lipid membranes as platforms for biophysical studies and advanced biosensors.- Chapter8: Biomedical Applications: Liposomes and Supported Lipid Bilayers for Diagnostics, Theranostics, Imaging, Vaccine Formulation, and Tissue Engineering.- Chapter9: Lipid Bilayers and Liposomes on Microfluidics Realm: Techniques and Applications.- Chapter10: Biomimetic Model Membranes as Drug Screening Platforms.- Chapter11: Biomimetic Membranes as an Emerging Water Filtration Technology.- Chapter12: Applications of lipid membranes based biosensors for the rapid detection of food toxicants and environmental pollutants.

O autorze

Dr. Fatma Neşe KÖK is currently Associated Professor in the Molecular Biology and Genetics Department of Istanbul Technical University, Turkey. She graduated from the Chemical Engineering Department at the Middle East Technical University and received her M.Sc. and Ph.D degrees from Biotechnology Program at the same University in 1997 and 2001, respectively. After receiving a postdoctoral research fellowship from the Alexander von Humboldt Foundation, she spent 2.5 years in Germany, in a joint project of Max Planck Institute (MPI) for Polymer Research (Mainz) and MPI for Biochemistry (Martinstred) (2002-2005) working on artificial lipid membranes. Her research interests include biomaterials and tissue engineering scaffold design, biosensors, controlled release systems, and construction and characterization of artificial lipid bilayers. 

Dr. Ahu Arslan Yildiz is currently Assistant Professor in the Bioengineering Department at the Izmir Institute of Technology (IZTECH). Previously, she was an Assistant Professor at Okan University's Genetics and Bioengineering Department and a visiting fellow at the Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine. She received her BSc degree in Chemistry in 2003 from Hacettepe University and the MSc degree in 2006 in Chemistry from Middle East Technical University. She received her Ph.D. in Biology in 2010 from the Max-Planck Institute Polymer Research and Johannes Gutenberg University. She specializes in the field of artificial cell membrane and membrane receptor research. Her research interests include applications of biotechnology, including biomimetic systems, biomaterials, tissue engineering and regenerative medicine, 3D cell culture, diagnostic tools, drug screening and lab-on-a-chip microfluidic devices.

Dr. Fatih Inci is currently working as a Research Scientist (Faculty/Academic Staff) at Stanford University School of Medicine, Canary Center at Stanford for Cancer Early Detection. Dr. Inci received his PhD degree from Istanbul Technical University (Turkey), focusing on artificial lipid membranes and their clinical and pharmaceutical applications on surface-sensitive platforms. During his Ph.D. studies, he was also appointed as a visiting scientist at the University of New South Wales (Sydney, Australia) and University of Technology Sydney (Australia). He also worked as a research scholar at Brigham and Women’s Hospital (BWH)-Harvard Medical School, and Harvard-MIT Health Sciences and Technology Division (Boston, MA, United States). Dr. Inci was then appointed a Postdoctoral Research Fellow at BWH-Harvard Medical School and Stanford University School of Medicine (Palo Alto, CA, United States) in 2013 and 2014, respectively. Dr. Inci’s area of excellence in research is to create micro- and nano-scale platform technologies in the fields of biomedical engineering, biotechnology and medicine by manipulating biomolecules, cells, and viruses in micro and nano-scale entities. His platform offers precise solutions for real-world challenges in clinical diagnostics, personalized medicine, cancer early detection, forensic science, and biomarker discovery. His research interests also focus on many applications of microfluidics, biosensors, nanoplasmonics, lab-on-a-chip, artificial lipid membranes, disease on-chip models, and drug delivery systems.

Blurb

This book compiles the fundamentals, applications and viable product strategies of biomimetic lipid membranes into a single, comprehensive source. It broadens its perspective to interdisciplinary realms incorporating medicine, biology, physics, chemistry, materials science, as well as engineering and pharmacy at large. The book guides readers from membrane structure and models to biophysical chemistry and functionalization of membrane surfaces. It then takes the reader through a myriad of surface-sensitive techniques before delving into cutting-edge applications that could help inspire new research directions. With more than half the world's drugs and various toxins targeting these crucial structures, the book addresses a topic of major importance in the field of medicine, particularly biosensor design, diagnostic tool development, vaccine formulation, micro/nano-array systems, and drug screening/development.

• Provides fundamental knowledge on biomimetic lipid membranes;
• Addresses some of biomimetic membrane types, preparation methods, properties and characterization techniques;
• Explains state-of-art technological developments that incorporate microfluidic systems, array technologies, lab-on-a-chip-tools, biosensing, and bioprinting techniques;
• Describes the integration of biomimetic membranes with current top-notch tools and platforms;
• Examines applications in medicine, pharmaceutical industry, and environmental monitoring.