Possible mechanisms of methylmercury neurotoxicity

ISBN-13: 9783846585504 / Angielski / Miękka / 2012 / 104 str.

Ezzat Awad

Opis

Different studies reported that glutathione (GSH) play a major role in modulating methylmercury (MeHg) neurotoxicity. Glutathione synthetase deficiency (GSD) and 5- Oxoprolinase deficiencies are two inborn errors of GSH metabolism; which were associated with physiological and pathological features resembling patients with Minamata disease (MD). The present study aimed to investigate whether there are similarities between the metabolic effects of MeHg and 5-oxoprolinase inhibitor (ICA) on both C6 Glial cells and PC12 neurons.

O autorze

Ezzat Awad Neuropsychiatrist specialist , gained master in neuroscience from the Norwegian university of science and technology in September 2011. Graduated from Ain Shams university faculty of medicine in Cairo , Egypt 2003 . Worked in different medical hospitals , research centers and participated in many academic and clinical researches.