A Proteomic Approach for Bordetella Pertussis : Identification of the New Immunogenic Proteins of Bordetella pertussis, the Causative Agent of Whooping Cough, by Immunoproteomics

ISBN-13: 9783639141092 / Angielski / Miękka / 2009 / 120 str.

Emrah Altindis

Opis

The genus Bordetella contains several pathogenic§species generally associated with upper respiratory§tract infections in warm-blooded animals. Bordetella§pertussis is the etiologic agent of whooping cough.§Whooping cough is presently one of the ten most§common causes of death from infectious diseases and§reported by the World Health Organisation (WHO) to§cause 50 million cases and 350000 deaths worldwide§per year.§The term proteome, in analogy to the term genome, was§coined to describe the complete set of proteins that§an organism has produced under a defined set of§conditions. Proteomics has been used to identify§novel bacterial vaccine candidates against several§human pathogens. Much of information about§immunogenic component can be derived from proteomics§coupled to Western blotting, namely immunoproteomics. §§In the present study, we report first§immunoproteomics analysis to identify candidate§antigens of B. pertussis for vaccine development.§Different sera from mice, which were immunized or§challenged with B. pertussis, were analyzed for§reactivity by Western blot against whole cell§extracts of B. pertussis Tohama and Saadet strains§separated by 2-DE.

O autorze

A better system for humankind is possible,so I have chosen the
way of science to live.Vaccinology and Proteomics are the areas
that I am interested in.I got my BSc degree at Bioengineering
Department of Ege University (2004) and had my MSc degree in
Department of Biotechnology of METU (2007).I have been doing my
PhD in Bologna University (2008-..)