Evaluation of the Antiepileptic Activity

ISBN-13: 9783639146356 / Angielski / Miękka / 2009 / 52 str.

Emile Bienvenu

Opis

To investigated in L. leonurus the anticonvulsant properties and the possible mechanism of action. Seizures were induced in mice with injection of doses of pentylenetetrazole, picrotoxin, bicuculline and N-methyl-DL-aspartic acid. The ability of the plant extract to prevent or prolong the tonic hind-limb extensor reflex was assessed. The results were statistically analyzed using the paired Student's t-test and Chi- squared test. L. leonurus extract in the doses of 200 and 400 mg/kg respectively protected 37.5% and 50% of animals used and significantly (p

O autorze

Emile BIENVENU is a Lecturer of Pharmacology and Therapeutics at the National University of Rwanda (NUR). He researches on drug rational use and therapy optimization. He participated in drafting Rwandan Formulary and Standard Treatment Guidelines, served in research administration at NUR and sits as a board member of Rwanda Bureau of Standards.