T-cell Receptor Gamma Gene Rearrangement in T-cell Neoplasm : Detection Using Genescan

ISBN-13: 9783659859090 / Angielski / Miękka / 2016 / 176 str.

Eman Adel

Opis

The discrimination between reactive and malignant cell populations in some patients with suspected T-cell lymphoproliferative disorders can be complicated and less straightforward. Often, the dilemma lies in determining whether a population of lymphocytes is reactive or neoplastic. In such cases, T-cell receptor (TCR)gene clonality studies have proved useful as an additional diagnostic tool. The TCRGamma gene is a preferred target for TCR gene clonality as it is rearranged at an early stage of T lymphoid development, rearranged in a large percent of T-cell neoplasms, and also because of its relative structural simplicity.

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O autorze

Eman A. Soliman, M.Sc, studied at faculty of Science at Mansoura University. Works as a medical analysis specialist in Oncology center at Mansoura University. Expert in molecular biology fields including PCR, Genescan and Sequencing techniques.