Manual of Hematopoietic Cell Transplantation and Cellular Therapies

ISBN-13: 9780323798334 / Angielski / Twarda / 2023

Qaiser Bashir; Elizabeth J. Shpall; Richard E. Champlin

Opis

Led by authors from MD Anderson's Stem Cell Transplantation and Cellular Therapy Department, the world's largest and highly respected program at the forefront of rapidly advancing treatments in the field, Manual of Hematopoietic Cell Transplantation and Cellular Therapies is a comprehensive, focused reference covering the latest clinical developments and applications of stem cell transplant and cellular therapies for hematologic malignancies and solid tumors. This cutting-edge title, with a majority contribution from the MD Anderson Cancer Center and leading faculty from other academic institutions, covers breakthrough cell-based therapies for various diseases including lymphoma, multiple myeloma, leukemia, and select solid tumor and autoimmune diseases. This unique, definitive resource is essential for hematologists, fellows in hematology and immunotherapy, mid-level providers, pharmacists, and oncologists who refer patients for cell-based therapies. Addresses hematologic conditions including leukemia, lymphoma, and myeloma.  Offers guidance on hematopoietic cell transplantation for solid tumors.    Covers basic science principles, clinical aspects, pharmacology, radiation therapy, and disease-specific guidelines, including prevention and management of complications.  Discusses key topics such as hematopoietic cell collection, bone marrow harvesting, umbilical cord blood transplantation, CAR T-cell therapy, and patient/donor selection and preparation of HCT.  Features extensive summary boxes, bulleted content, and algorithms throughout for quick and easy reference.  Offers team-based, clinically-focused coverage from world-renowned leaders in the field.  An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. 

Spis treści

Part One Introduction

Ch 1 Evolution of HCT, past, present, and future

Ch 2 Human leukocyte antigen

Ch 3 Introduction and basic science of chimeric antigen receptor therapies

Ch 4 Statistical methods in HCT and cellular therapies

Part Two Methodology

Ch 5 Hematopoietic cell collection; bone marrow harvesting, apheresis, UCB

Ch 6 Leukapheresis and manufacturing of CAR cells

Part Three General Clinical Aspects

Ch 7 Patient and donor selection and preparing for HCT

Ch 8 General management of patients undergoing HCT

Ch 9 Haploidentical HCT

Ch 10 Umbilical cord blood transplantation

Ch 11 Process and general management of patients undergoing CAR therapies

Part Four Pharmacology and Radiation Therapy

Ch 12 Preparative regimens used in HCT and CAR therapies

Ch 13 Pharmacology of drugs used in HCT and CAR therapies

Ch 14 Role of radiation therapy in HCT and CAR therapies

Part Five Disease-Specific Indications and Results

Ch 15 HCT in AML

Ch 16 CAR therapy in AML

Ch 17 HCT in ALL

Ch 18 CAR therapy in ALL

Ch 19 HCT in chronic leukemias; CML and CLL

Ch 20 HCT in MDS

Ch 21 HCT in myeloproliferative disorders

Ch 22 HCT in aplastic anemia

Ch 23 HCT in multiple myeloma

Ch 24 CAR therapy in multiple myeloma

Ch 25 HCT in light-chain amyloidosis

Ch 26 HCT in NHL

Ch 27 HCT in Hodgkin lymphoma

Ch 28 CAR therapy in lymphoma

Ch 29 HCT in rare malignancies

Ch 30 HCT for hematologic malignancies in HIV patients

Ch 31 HCT in solid tumors

Part Six Prevention and Management of Complications

Ch 32 Infectious complications

Ch 33 Graft failure

Ch 34 Graft-versus-host disease

Ch 35 Miscellaneous complications of HCT

Ch 36 Cytokine release syndrome

Ch 37 Neurologic complications of CAR therapy (ICANS)

Ch 38 Miscellaneous complications of CAR therapy

Ch 39 Symptoms management and palliative care

Ch 40 Survivorship