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As nutrition research is shifting its focus from epidemiology and physiology to effects of nutrients at the molecular level, a uniquely tailored diet that corresponds to the demands of our genetic signature is emerging as an indispensable need. Using high-throughput genomic tools, nutrigenomics unravels the influence of micro- and macronutrients as potent dietary signals regulating metabolic pathways and unmasks how susceptible genotypes are predisposed to diet-related diseases.

Selected topics from this field have been covered in some books, but no other comprehensive text on...

With cardiovascular disease remaining one of the primary causes of morbidity and mortality worldwide, there is a great need to further understand the molecular basis of this disease class and develop new therapeutic or preventative measures. Cardiovascular Diseases: Nutritional and Therapeutic Interventions presents up-to-date information on the pathobiology of cardiovascular diseases, emphasizing emerging therapeutics and nutritional interventions. The book is divided into four parts: epidemiology, epigenetics, pathobiology, and therapies for cardiovascular diseases.
Part I details...

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The...

Designed for easy reference, this concise manual provides hospital board members and executives with practical guidance on how to become actively engaged in the transformation of their organization. It focuses on how the healthcare industry as a whole is transforming and stresses the importance of having board members who are knowledgeable and skilled enough to provide leadership during this time of great opportunity.

This manual is ideal for orienting new board members and for providing more experienced members with insight on key issues. It supplies a list of questions to ask...