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From modest Quaker beginnings as the child of financially insecure parents and the wife of a stolid young lawyer to the excitement and challenges of life as the nation's first First Lady--arguably the most influential role in the American government's formative years--Dolley Payne Todd Madison (1768-1849) led an extraordinary life. David B. Mattern and Holly C. Shulman have culled a particularly rich selection of her letters to illuminate the story of the woman widely credited with setting the standard for successive generations of Washington's political women. This collection will prove...

Mild Cognitive Impairment (MCI) has been identified as an important clinical transition between normal aging and the early stages of Alzheimer's disease (AD). Since treatments for AD are most likely to be most effective early in the course of the disease, MCI has become a topic of great importance and has been investigated in different populations of interest in many countries. This book brings together these differing perspectives on MCI for the first time.

This volume provides a comprehensive resource for clinicians, researchers, and students involved in the study, diagnosis,...

Mild Cognitive Impairment (MCI) has been identified as an important clinical transition between normal aging and the early stages of Alzheimer's disease (AD). Since treatments for AD are most likely to be most effective early in the course of the disease, MCI has become a topic of great importance and has been investigated in different populations of interest in many countries. This book brings together these differing perspectives on MCI for the first time.

This volume provides a comprehensive resource for clinicians, researchers, and students involved in the study, diagnosis,...

Physical cultural studies (PCS) is a dynamic and rapidly developing field of study. This handbook offers the first definitive account of the state of the art in PCS, showcasing the latest research and methodological approaches. It examines the boundaries, preoccupations, theories and politics of PCS, drawing on transdisciplinary expertise from areas as diverse as sport studies, sociology, history, cultural studies, performance studies and anthropology.

Featuring chapters written by world-leading scholars, this handbook examines the most important themes and issues within PCS,...

Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were...