Eicosanoids, Lipid Peroxidation and Cancer

ISBN-13: 9783540189329 / Angielski / Miękka / 1989 / 362 str.

Santosh K. Nigam; David C. H. McBrien; Trevor F. Slater

Opis

This volume offers you up-to-date, expert reviews of this fast-moving field.The main topics are based on the interrelationships between arachidonate metabolism, platelet-activating factor, lipid peroxidation and cancer. The reviews provide vital information for the specialist and will also be of value to a wide audience interested in developments in cell biology, pharmacology, pathology, biochemistry and cancer.

Spis treści

Thromboxane A2 and Prostacyclin in Tumorigenesis.- Tumour Promoters and Prostaglandin Production.- Eicosanoid Regulation of Macrophage In Vitro Cytostatic function Towards Tumour Cells.- Role of Tumour Cell Eicosanoids and Membrane Glycoproteins IRGPIb and IRGPIIb/IIIa in Metastasis.- Alteration of Arachidonic Acid Metabolism in Rats after Inoculation of Tumour Cells and Their Subcellular Fractions: Role of Mononuclear Phagocytes as a Major Source of Enhanced Prostanoid Synthesis.- The Role of Platelet-Activating Factor and Structurally Related Alkyl Phospholipids in Immune and Cytotoxic Processes.- Platelet-Activating Factor in Renal Pathophysiology: The Effects of PAF Antagonists.- Interaction of Macrophages and Mast Cells in the Production of Prostaglandins and Leukotrienes.- Prostaglandin E2 and Thromboxane A2 Production by Human Peritoneal Macrophages: Effect of Mitomycin C, Nitrogen Mustard and Cyclosporin A.- Uterine Lipoxygenase Pathways.- Modulation of Ocular Eicosanoid Biosynthesis by Oxidants and Antioxidants.- Endogenous Formation of Leukotriene D4 During Systematic Anaphylaxis in the Guinea Pig.- Theoretical Calculations of the Structures of Some Prostaglandins and Inhibitors of Lipoxygenase.- Lipid Peroxidation and Cell Division in Normal and Tumour Tissues.- The Involvement of Free Radicals and Lipid Peroxidation in Carcinogenesis.- Diene Conjugation and Peroxidation in Precancer.- Oxygen Radical Regulation of Vascular Reactivity.- Arachidonic Acid-Induced Activation of NADPH Oxidase in Membranes of Human Neutrophils and HL-60 Leukemic Cells is Regulated by Guanine Nucleotide-Binding Proteins and is Independent of Ca2+ and Protein Kinase C.- Biochemistry of Oxidative Stress: Recent Experimental Work.- Lipid Peroxidation and Irreversible Hepatocyte Damage.- Lipid Peroxidation, Antioxidants and Regenerating Rat Liver.- Effect of Peroxidative Conditions on Human Plasma Low-Density Lipoproteins.- Studies on the Oxygen Dependance of Lipid Peroxidation.- Iron-Induced Lipid Peroxidation and Inhibition of Proliferation in Animal Tumour Cells.- Ethane and n-Pentane Formation in a Reconstituted Microsomal Lipid Peroxidation System.- The CCl4-Induced Increase of Free Arachidonate in Hepatocytes.- Lipid Peroxidation Products and Carcinogenesis: Preliminary Evidence of n-Alkanal Genotoxicity.- Detection of 4-Hydroxynonenal and Other Lipid Peroxidation Products in the Liver of Allyl Alcohol-Intoxicated Mice.- Liver Cell Heterogeneity in Biotransformation of Carcinogenic Polycyclic Hydrocarbons.- Free Radical Intermediates of Carcinogenic Hydrazines.- Studies on Cancer of the Human Cervix in Relation to Thiol-Groups.- Microphotometric Determination of Protein Thiols and Disulphides in Tissue Samples from the Human Uterine Cervix and the Skin Reveal a “Field Effect” in the Surroundings of Benign and Malignant Tumours.- Protein-Thiol Levels in Relation to Deviation from Normality in Rat Liver Cell Lines.- Computerized Digital Video Microdensitometry Applied to the Quantitation of Intracellular Macromolecules or Their Functional Groups.- Modulation of Hepatocarcinogenicity of Aflatoxin B1 by the Chlorinated Insecticide DDT.- Intratumoral Fibrin Stabilization.